7XTQ
 
 | | Cryo-EM structure of the R399-bound GPBAR-Gs complex | | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | | Deposit date: | 2022-05-17 | | Release date: | 2022-07-06 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5CRL
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3O72
 | | Crystal structure of EfeB in complex with heme | | Descriptor: | OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, Redox component of a tripartite ferrous iron transporter | | Authors: | Liu, X, Du, Q, Wang, Z, Zhu, D, Huang, Y, Li, N, Xu, S, Gu, L. | | Deposit date: | 2010-07-30 | | Release date: | 2011-03-16 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure and biochemical features of EfeB/YcdB from Escherichia coli O157: ASP235 plays divergent roles in different enzyme-catalyzed processes
J.Biol.Chem., 286, 2011
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4LA3
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4LA2
 | | Crystal structure of dimethylsulphoniopropionate (DMSP) lyase DddQ | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Dimethylsulphoniopropionate (DMSP) lyase DddQ, ZINC ION | | Authors: | Zhang, Y, Li, C. | | Deposit date: | 2013-06-19 | | Release date: | 2014-01-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide
Proc.Natl.Acad.Sci.USA, 111, 2014
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3TLQ
 | | Crystal structure of EAL-like domain protein YdiV | | Descriptor: | GLYCEROL, PHOSPHATE ION, Regulatory protein YdiV | | Authors: | Li, B, Li, N, Wang, F, Guo, L, Liu, C, Zhu, D, Xu, S, Gu, L. | | Deposit date: | 2011-08-30 | | Release date: | 2012-09-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
Nucleic Acids Res., 40, 2012
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7DNR
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5XSN
 | | The catalytic domain of GdpP with c-di-AMP | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, MANGANESE (II) ION, Phosphodiesterase acting on cyclic dinucleotides | | Authors: | Wang, F, Gu, L. | | Deposit date: | 2017-06-14 | | Release date: | 2018-01-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
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5XSI
 | | The catalytic domain of GdpP | | Descriptor: | MANGANESE (II) ION, Phosphodiesterase acting on cyclic dinucleotides | | Authors: | Wang, F, Gu, L. | | Deposit date: | 2017-06-14 | | Release date: | 2018-01-31 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
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5XSP
 | | The catalytic domain of GdpP with 5'-pApA | | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, Phosphodiesterase acting on cyclic dinucleotides | | Authors: | Wang, F, Gu, L. | | Deposit date: | 2017-06-15 | | Release date: | 2018-01-31 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.146 Å) | | Cite: | Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
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5XT3
 | | The catalytic domain of GdpP with c-di-GMP | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MANGANESE (II) ION, Phosphodiesterase acting on cyclic dinucleotides | | Authors: | Wang, F, Gu, L. | | Deposit date: | 2017-06-16 | | Release date: | 2018-01-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.591 Å) | | Cite: | Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
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6A5Q
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6AKR
 | | Crystal structure of the PDE4D catalytic domain in complex with osthole | | Descriptor: | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | | Authors: | Wang, S, Huo, Y.W, Xie, Y. | | Deposit date: | 2018-09-03 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.326 Å) | | Cite: | Airway relaxation mechanisms and structural basis of osthole for improving lung function in asthma.
Sci.Signal., 13, 2020
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6A5S
 | | Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif | | Descriptor: | 14-3-3 protein gamma, MAGNESIUM ION, SODIUM ION, ... | | Authors: | Xu, Y, Ren, J.Q, Feng, W. | | Deposit date: | 2018-06-25 | | Release date: | 2019-02-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.099 Å) | | Cite: | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Autophagy, 15, 2019
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6JGF
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6JGV
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6JGW
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6JNI
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6K0J
 | | The co-crystal structure of DYRK2 with a small molecule inhibitor | | Descriptor: | 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | | Authors: | Tiantian, W, Xiao, J. | | Deposit date: | 2019-05-06 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.352 Å) | | Cite: | Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6JGX
 | | Crystal structure of the transcriptional regulator CadR from P. putida in complex with Cadmium(II) and DNA | | Descriptor: | CADMIUM ION, CadR, DNA (5'-D(*CP*AP*CP*CP*CP*TP*AP*TP*AP*GP*TP*GP*GP*CP*TP*AP*CP*AP*GP*GP*GP*T)-3'), ... | | Authors: | Liu, X.C, Gan, J.H, Chen, H. | | Deposit date: | 2019-02-15 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
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