6K0J

The co-crystal structure of DYRK2 with a small molecule inhibitor

Summary for 6K0J

Entry DOI	10.2210/pdb6k0j/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 2, 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine (3 entities in total)
Functional Keywords	kinase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38099.10
Authors	Tiantian, W.,Xiao, J. (deposition date: 2019-05-06, release date: 2019-11-20, Last modification date: 2019-12-18)
Primary citation	Banerjee, S.,Wei, T.,Wang, J.,Lee, J.J.,Gutierrez, H.L.,Chapman, O.,Wiley, S.E.,Mayfield, J.E.,Tandon, V.,Juarez, E.F.,Chavez, L.,Liang, R.,Sah, R.L.,Costello, C.,Mesirov, J.P.,de la Vega, L.,Cooper, K.L.,Dixon, J.E.,Xiao, J.,Lei, X. Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression. Proc.Natl.Acad.Sci.USA, 116:24881-24891, 2019 Cited by PubMed: 31754034 DOI: 10.1073/pnas.1912033116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.352 Å)

Structure validation