6K0J
The co-crystal structure of DYRK2 with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | polymer | 327 | 37770.7 | 1 | UniProt (Q92630) Pfam (PF00069) | Homo sapiens (Human) | |
| 2 | B (A) | 3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine | non-polymer | 328.4 | 1 | Chemie (CQO) | |||
| 3 | C (A) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A: 212 - 536 (UniProt: Q92630)
| PDB | External Database | Details |
|---|---|---|
| Asn 256 | Glu 256 | engineered mutation |
| Ala 349 | Leu 349 | engineered mutation |
| Ala 537 | - | expression tag |
| Ala 538 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37770.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 328.4 | |
| All* | Total formula weight | 38099.1 |
