5XTB
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![BU of 5xtb by Molmil](/molmil-images/mine/5xtb) | Cryo-EM structure of human respiratory complex I matrix arm | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Gu, J, Wu, M, Yang, M. | Deposit date: | 2017-06-18 | Release date: | 2017-08-30 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2. Cell, 170, 2017
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6YPZ
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![BU of 6ypz by Molmil](/molmil-images/mine/6ypz) | Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Monooxygenase, ... | Authors: | Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. | Deposit date: | 2020-04-16 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
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6YQ6
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![BU of 6yq6 by Molmil](/molmil-images/mine/6yq6) | Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Monooxygenase, ... | Authors: | Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. | Deposit date: | 2020-04-16 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
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6YQ3
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![BU of 6yq3 by Molmil](/molmil-images/mine/6yq3) | Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis | Descriptor: | (3~{R})-8-methoxy-3-methyl-3,6-bis(oxidanyl)-2,4-dihydrobenzo[a]anthracene-1,7,12-trione, 1,2-ETHANEDIOL, Monooxygenase, ... | Authors: | Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. | Deposit date: | 2020-04-16 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
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6YQ0
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![BU of 6yq0 by Molmil](/molmil-images/mine/6yq0) | Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis | Descriptor: | (3~{R})-8-methoxy-3-methyl-3-oxidanyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione, 1,2-ETHANEDIOL, Monooxygenase, ... | Authors: | Xiao, X, Elsayed, S.S, Wu, C, van der Heul, H, Prota, A, Huang, J, Guo, R, Abrahams, J.P, van Wezel, G.P. | Deposit date: | 2020-04-16 | Release date: | 2020-09-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. Acs Chem.Biol., 15, 2020
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8FTS
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![BU of 8fts by Molmil](/molmil-images/mine/8fts) | SgvM methyltransferase with SAH and alpha-ketoleucine | Descriptor: | 2-OXO-4-METHYLPENTANOIC ACID, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Kuzelka, K, Nair, S.K. | Deposit date: | 2023-01-13 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A biocatalytic platform for asymmetric alkylation of alpha-keto acids by mining and engineering of methyltransferases Nat Commun, 14, 2023
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8FTV
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8FTR
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![BU of 8ftr by Molmil](/molmil-images/mine/8ftr) | SgvM methyltransferase with MTA and alpha-ketoleucine | Descriptor: | 2-OXO-4-METHYLPENTANOIC ACID, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methyltransferase, ... | Authors: | Kuzelka, K, Nair, S.K. | Deposit date: | 2023-01-13 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | A biocatalytic platform for asymmetric alkylation of alpha-keto acids by mining and engineering of methyltransferases. Nat Commun, 14, 2023
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3Q96
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![BU of 3q96 by Molmil](/molmil-images/mine/3q96) | B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor | Descriptor: | (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide, Serine/threonine-protein kinase B-raf | Authors: | Sintchak, M.D, Aertgeerts, K, Yano, J. | Deposit date: | 2011-01-07 | Release date: | 2011-03-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors. J.Med.Chem., 54, 2011
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3SOW
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![BU of 3sow by Molmil](/molmil-images/mine/3sow) | |
3SOU
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![BU of 3sou by Molmil](/molmil-images/mine/3sou) | |
3SOX
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![BU of 3sox by Molmil](/molmil-images/mine/3sox) | Structure of UHRF1 PHD finger in the free form | Descriptor: | E3 ubiquitin-protein ligase UHRF1, ZINC ION | Authors: | Rajakumara, E, Patel, D.J. | Deposit date: | 2011-06-30 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6501 Å) | Cite: | PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression. Mol.Cell, 43, 2011
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3WBM
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![BU of 3wbm by Molmil](/molmil-images/mine/3wbm) | Crystal Structure of protein-RNA complex | Descriptor: | DNA/RNA-binding protein Alba 1, RNA (25-MER) | Authors: | Ding, J, Wang, D.C. | Deposit date: | 2013-05-20 | Release date: | 2013-12-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and structural insights into RNA binding by Ssh10b, a member of the highly conserved Sac10b protein family in Archaea. J.Biol.Chem., 289, 2014
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8U37
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![BU of 8u37 by Molmil](/molmil-images/mine/8u37) | Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with NVP-CJL037 at 2.48-A resolution | Descriptor: | (6M)-3-amino-N-{4-[(3R,4S)-4-amino-3-methoxypiperidin-1-yl]pyridin-3-yl}-6-[3-(trifluoromethoxy)pyridin-2-yl]pyrazine-2-carboxamide, MAGNESIUM ION, Protein kinase C alpha type | Authors: | Romanowski, M.J, Lam, J, Visser, M. | Deposit date: | 2023-09-07 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma. J.Med.Chem., 67, 2024
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8UAK
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![BU of 8uak by Molmil](/molmil-images/mine/8uak) | Crystal structure of the catalytic domain of human PKC alpha (D463N, V568I, S657E) in complex with Darovasertib (NVP-LXS196) at 2.82-A resolution | Descriptor: | (6M)-3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide, Protein kinase C alpha type | Authors: | Romanowski, M.J, Lam, J, Visser, M. | Deposit date: | 2023-09-21 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma. J.Med.Chem., 67, 2024
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6ABO
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![BU of 6abo by Molmil](/molmil-images/mine/6abo) | human XRCC4 and IFFO1 complex | Descriptor: | DNA repair protein XRCC4, GLYCEROL, Intermediate filament family orphan 1, ... | Authors: | Li, J, Liu, L, Liang, H, Liu, Y, Xu, D. | Deposit date: | 2018-07-23 | Release date: | 2019-07-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nat.Cell Biol., 21, 2019
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7VKA
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![BU of 7vka by Molmil](/molmil-images/mine/7vka) | Crystal Structure of GH3.6 in complex with an inhibitor | Descriptor: | ADENOSINE MONOPHOSPHATE, GLYCEROL, Indole-3-acetic acid-amido synthetase GH3.6, ... | Authors: | Wang, N, Luo, M, Bao, H, Huang, H. | Deposit date: | 2021-09-29 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation. Proc.Natl.Acad.Sci.USA, 119, 2022
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6J5I
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![BU of 6j5i by Molmil](/molmil-images/mine/6j5i) | Cryo-EM structure of the mammalian DP-state ATP synthase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F1 subunit epsilon, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-11 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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6J54
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![BU of 6j54 by Molmil](/molmil-images/mine/6j54) | Cryo-EM structure of the mammalian E-state ATP synthase FO section | Descriptor: | ATP synthase membrane subunit 6.8PL, ATP synthase membrane subunit DAPIT, ATP synthase peripheral stalk-membrane subunit b, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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6J5A
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![BU of 6j5a by Molmil](/molmil-images/mine/6j5a) | Cryo-EM structure of the mammalian DP-state ATP synthase FO section | Descriptor: | ATP synthase membrane subunit 6.8PL, ATP synthase membrane subunit DAPIT, ATP synthase peripheral stalk-membrane subunit b, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-10 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.35 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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6J5K
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![BU of 6j5k by Molmil](/molmil-images/mine/6j5k) | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F1 subunit alpha, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-11 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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6J5J
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![BU of 6j5j by Molmil](/molmil-images/mine/6j5j) | Cryo-EM structure of the mammalian E-state ATP synthase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F1 subunit epsilon, ... | Authors: | Gu, J, Zhang, L, Yi, J, Yang, M. | Deposit date: | 2019-01-11 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364, 2019
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6K7Y
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![BU of 6k7y by Molmil](/molmil-images/mine/6k7y) | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, CALCIUM ION, CARDIOLIPIN, ... | Authors: | Zhuo, W, Zhou, H, Yang, M. | Deposit date: | 2019-06-10 | Release date: | 2020-09-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of intact human MCU supercomplex with the auxiliary MICU subunits. Protein Cell, 12, 2021
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6K7X
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![BU of 6k7x by Molmil](/molmil-images/mine/6k7x) | Human MCU-EMRE complex | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, CALCIUM ION, CARDIOLIPIN, ... | Authors: | Zhuo, W, Zhou, H, Yang, M. | Deposit date: | 2019-06-10 | Release date: | 2020-09-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structure of intact human MCU supercomplex with the auxiliary MICU subunits. Protein Cell, 12, 2021
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5Z62
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![BU of 5z62 by Molmil](/molmil-images/mine/5z62) | Structure of human cytochrome c oxidase | Descriptor: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, COPPER (II) ION, ... | Authors: | Gu, J, Zong, S, Wu, M, Yang, M. | Deposit date: | 2018-01-22 | Release date: | 2019-02-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the intact 14-subunit human cytochrome c oxidase. Cell Res., 28, 2018
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