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6YQ3

Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis

This is a non-PDB format compatible entry.
Summary for 6YQ3
Entry DOI10.2210/pdb6yq3/pdb
DescriptorMonooxygenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3~{R})-8-methoxy-3-methyl-3,6-bis(oxidanyl)-2,4-dihydrobenzo[a]anthracene-1,7,12-trione, ... (5 entities in total)
Functional Keywordslugdunomycin, keto-reduction, short chain alcohol reductase, rossmann fold, antibiotic
Biological sourceStreptomyces sp. QL37
Total number of polymer chains2
Total formula weight55910.12
Authors
Xiao, X.,Elsayed, S.S.,Wu, C.,van der Heul, H.,Prota, A.,Huang, J.,Guo, R.,Abrahams, J.P.,van Wezel, G.P. (deposition date: 2020-04-16, release date: 2020-09-16, Last modification date: 2024-01-24)
Primary citationXiao, X.,Elsayed, S.S.,Wu, C.,van der Heul, H.U.,Metsa-Ketela, M.,Du, C.,Prota, A.E.,Chen, C.C.,Liu, W.,Guo, R.T.,Abrahams, J.P.,van Wezel, G.P.
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 15:2529-2538, 2020
Cited by
PubMed: 32840360
DOI: 10.1021/acschembio.0c00564
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.57 Å)
Structure validation

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