6YQ0

Promiscuous Reductase LugOII Catalyzes Keto-reduction at C1 during Lugdunomycin Biosynthesis

This is a large structure.

Summary for 6YQ0

DescriptorMonooxygenase, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywordslugdunomycin, keto-reduction, short chain alcohol reductase, rossmann fold, antibiotic
Biological sourceStreptomyces sp. QL37
Total number of polymer chains2
Total molecular weight56622.93
Authors
Primary citation
Xiao, X.,Elsayed, S.S.,Wu, C.,van der Heul, H.U.,Metsa-Ketela, M.,Du, C.,Prota, A.E.,Chen, C.C.,Liu, W.,Guo, R.T.,Abrahams, J.P.,van Wezel, G.P.
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.
Acs Chem.Biol., 2020
PubMed: 32840360 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.0c00564
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.08 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.172300 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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168889
PDB entries from 2020-09-16