7VKA

Crystal Structure of GH3.6 in complex with an inhibitor

Summary for 7VKA

• Entry DOI: 10.2210/pdb7vka/pdb
• Descriptor: Indole-3-acetic acid-amido synthetase GH3.6, ADENOSINE MONOPHOSPHATE, N-[4-[(6-chloranylpyridazin-3-yl)amino]phenyl]-3-(trifluoromethyl)benzamide, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, ligase
• Biological source: Arabidopsis thaliana (Mouse-ear cress)
• Total number of polymer chains: 2
• Total formula weight: 139686.76

Authors

Wang, N.,Luo, M.,Bao, H.,Huang, H. (deposition date: 2021-09-29, release date: 2022-08-31, Last modification date: 2023-11-29)

• Primary citation: Xie, Y.,Zhu, Y.,Wang, N.,Luo, M.,Ota, T.,Guo, R.,Takahashi, I.,Yu, Z.,Aizezi, Y.,Zhang, L.,Yan, Y.,Zhang, Y.,Bao, H.,Wang, Y.,Zhu, Z.,Huang, A.C.,Zhao, Y.,Asami, T.,Huang, H.,Guo, H.,Jiang, K.; Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation.; Proc.Natl.Acad.Sci.USA, 119:e2209256119-e2209256119, 2022; PubMed: 36454752; DOI: 10.1073/pnas.2209256119

Experimental method

X-RAY DIFFRACTION (2.401 Å)