4R37
 
 | | Crystal structure analysis of LpxA, a UDP-N-acetylglucosamine acyltransferase from Bacteroides fragilis 9343 with UDP-GlcNAc | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ACETATE ION, ... | | Authors: | Fisher, A.J, Chen, X, Ngo, A. | | Deposit date: | 2014-08-14 | | Release date: | 2015-05-06 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA).
Acta Crystallogr.,Sect.D, 71, 2015
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4R83
 | | Crystal structure of Sialyltransferase from Photobacterium damsela | | Descriptor: | CALCIUM ION, Sialyltransferase 0160 | | Authors: | Fisher, A.J, Chen, X, Li, Y, Huynh, N. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-03 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae.
Febs Lett., 588, 2014
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4RZM
 | | Crystal structure of the Lsd19-lasalocid A complex | | Descriptor: | CHLORIDE ION, Epoxide hydrolase LasB, FORMIC ACID, ... | | Authors: | Mathews, I.I, Hotta, K, Chen, X, Kim, C.-Y. | | Deposit date: | 2014-12-22 | | Release date: | 2015-01-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.
J.Am.Chem.Soc., 137, 2015
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4KNB
 | | C-Met in complex with OSI ligand | | Descriptor: | 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE, Hepatocyte growth factor receptor | | Authors: | Wang, J, Steinig, A.G, Li, A.H, Chen, X, Dong, H, Ferraro, C, Jin, M, Kadalbajoo, M, Kleinberg, A, Stolz, K.M, Tavares-Greco, P.A, Wang, T, Albertella, M.R, Peng, Y, Crew, L, Kahler, J. | | Deposit date: | 2013-05-09 | | Release date: | 2014-04-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg.Med.Chem.Lett., 23, 2013
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4R84
 | | Crystal structure of Sialyltransferase from Photobacterium damsela with CMP-3F(a)Neu5Ac bound | | Descriptor: | CALCIUM ION, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, Sialyltransferase 0160 | | Authors: | Fisher, A.J, Chen, X, Li, Y, Huynh, N. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae.
Febs Lett., 588, 2014
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4R9V
 | | Crystal structure of sialyltransferase from photobacterium damselae, residues 113-497 corresponding to the gt-b domain | | Descriptor: | CALCIUM ION, Sialyltransferase 0160 | | Authors: | Li, Y, Huynh, N, Chen, X, Fisher, A.J. | | Deposit date: | 2014-09-08 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae.
Febs Lett., 588, 2014
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5GWZ
 | | The structure of Porcine epidemic diarrhea virus main protease in complex with an inhibitor | | Descriptor: | N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE, PEDV main protease | | Authors: | Wang, F, Chen, C, Yang, K, Liu, X, Liu, H, Xu, Y, Chen, X, Liu, X, Cai, Y, Yang, H. | | Deposit date: | 2016-09-14 | | Release date: | 2017-03-29 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.444 Å) | | Cite: | Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60, 2017
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9IS7
 | | Paracandidimonas lactea CP group II intron 2S state | | Descriptor: | MAGNESIUM ION, POTASSIUM ION, RNA (153-MER), ... | | Authors: | Wang, L, Xie, J.H, Zhang, C, Zou, J, Huang, Z, Shang, S, Chen, X, Yang, Y, Liu, J, Dong, H, Huang, D, Su, Z. | | Deposit date: | 2024-07-17 | | Release date: | 2025-02-12 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Structural basis of circularly permuted group II intron self-splicing.
Nat.Struct.Mol.Biol., 32, 2025
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9IJU
 | | Sertraline enhances the deubiquitinase activity of USP7 by binding to its switching loop region | | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Shi, L, Xu, Z, Chen, X, Xiong, B, Zhang, N. | | Deposit date: | 2024-06-25 | | Release date: | 2025-03-12 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Sertraline and Astemizole Enhance the Deubiquitinase Activity of USP7 by Binding to Its Switching Loop Region.
J.Med.Chem., 68, 2025
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9IML
 | | Sertraline enhances the deubiquitinase activity of USP7 by binding to its switching loop region | | Descriptor: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Shi, L, Xu, Z, Chen, X, Xiong, B, Zhang, N. | | Deposit date: | 2024-07-03 | | Release date: | 2025-03-12 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | Sertraline and Astemizole Enhance the Deubiquitinase Activity of USP7 by Binding to Its Switching Loop Region.
J.Med.Chem., 68, 2025
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9JFB
 | | Crystal structure of L-threonine-O-3-phosphate decarboxylase CobC | | Descriptor: | CHLORIDE ION, GLYCEROL, SODIUM ION, ... | | Authors: | Jiang, M, Guo, S, Chen, X, Wei, Q, Wang, M. | | Deposit date: | 2024-09-04 | | Release date: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of l-threonine-O-3-phosphate decarboxylase CobC from Sinorhizobium meliloti involved in vitamin B 12 biosynthesis.
Biochem.Biophys.Res.Commun., 734, 2024
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9JFF
 | | Crystal structure of L-threonine-O-3-phosphate decarboxylase CobC in complex with reaction intermediate | | Descriptor: | CHLORIDE ION, GLYCEROL, SODIUM ION, ... | | Authors: | Jiang, M, Guo, S, Chen, X, Wei, Q, Wang, M. | | Deposit date: | 2024-09-04 | | Release date: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of l-threonine-O-3-phosphate decarboxylase CobC from Sinorhizobium meliloti involved in vitamin B 12 biosynthesis.
Biochem.Biophys.Res.Commun., 734, 2024
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9K36
 | | Human RNA Polymerase III de novo transcribing complex 12 (TC12) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (54-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K3V
 | | Human RNA Polymerase III de novo transcribing complex 4 (TC4) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (96-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-20 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K2G
 | | Human RNA Polymerase III de novo transcribing complex 13 (TC13) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (104-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-17 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K39
 | | Human RNA Polymerase III de novo transcribing complex 8 (TC8) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (50-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K3U
 | | Human RNA Polymerase III de novo transcribing complex 5 (TC5) | | Descriptor: | DNA (97-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-20 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K38
 | | Human RNA Polymerase III de novo transcribing complex 6 (TC6) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (51-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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9K3B
 | | Human RNA Polymerase III de novo transcribing complex 10 overall (TC10-overall) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (102-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2024-10-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 2025
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7V9M
 | | Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. | | Deposit date: | 2021-08-26 | | Release date: | 2021-10-20 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Constitutive signal bias mediated by the human GHRHR splice variant 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
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2PFD
 | | Anisotropically refined structure of FTCD | | Descriptor: | Formimidoyltransferase-cyclodeaminase | | Authors: | Poon, B.K, Chen, X, Lu, M, Quiocho, F.A, Wang, Q, Ma, J. | | Deposit date: | 2007-04-04 | | Release date: | 2007-04-24 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Anisotropically refined structure of FTCD
To be Published
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3G5C
 | | Structural and biochemical studies on the ectodomain of human ADAM22 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 22, CALCIUM ION | | Authors: | Liu, H, Shim, A, Chen, X, He, X. | | Deposit date: | 2009-02-04 | | Release date: | 2009-08-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural and biochemical studies on the ectodomain of human ADAM22
J.Biol.Chem., 2009
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2HDC
 | | STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX | | Descriptor: | DNA (5'-D(P*GP*CP*TP*TP*AP*AP*AP*AP*TP*AP*AP*CP*AP*AP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*TP*TP*GP*TP*TP*AP*TP*TP*TP*TP*AP*AP*GP*C)-3'), PROTEIN (TRANSCRIPTION FACTOR) | | Authors: | Jin, C, Marsden, I, Chen, X, Liao, X. | | Deposit date: | 1999-05-05 | | Release date: | 1999-07-05 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex.
J.Mol.Biol., 289, 1999
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4GQH
 | | The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies | | Descriptor: | Capsid protein | | Authors: | Li, X.Y, Song, B.A, Hu, D.Y, Chen, X, Wang, Z.C, Zeng, M.J, Yu, D.D, Chen, Z, Jin, L.H, Yang, S. | | Deposit date: | 2012-08-23 | | Release date: | 2013-08-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | The Conformations and Interactions of the Four-Layer Aggregate Revealed by X-ray Crystallography Diffraction Implied the Importance of Peptides at Opposite Ends in Their Assemblies
To be Published
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7RNS
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