7V9M

Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex

Summary for 7V9M

• Entry DOI: 10.2210/pdb7v9m/pdb
• EMDB information: 31825
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Nanobody-35, ... (6 entities in total)
• Functional Keywords: class b gpcr, receptor bias, cancer, cell proliferation, structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 172041.73

Authors

Cong, Z.T.,Zhou, F.L.,Zhang, C.,Zou, X.Y.,Zhang, H.B.,Wang, Y.Z.,Zhou, Q.T.,Cai, X.Q.,Liu, Q.F.,Li, J.,Shao, L.J.,Mao, C.Y.,Wang, X.,Wu, J.H.,Xia, T.,Zhao, L.H.,Jiang, H.L.,Zhang, Y.,Xu, H.E.,Chen, X.,Yang, D.H.,Wang, M.W. (deposition date: 2021-08-26, release date: 2021-10-20, Last modification date: 2024-06-19)

• Primary citation: Cong, Z.,Zhou, F.,Zhang, C.,Zou, X.,Zhang, H.,Wang, Y.,Zhou, Q.,Cai, X.,Liu, Q.,Li, J.,Shao, L.,Mao, C.,Wang, X.,Wu, J.,Xia, T.,Zhao, L.H.,Jiang, H.,Zhang, Y.,Xu, H.E.,Cheng, X.,Yang, D.,Wang, M.W.; Constitutive signal bias mediated by the human GHRHR splice variant 1.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34599099; DOI: 10.1073/pnas.2106606118

Experimental method

ELECTRON MICROSCOPY (3.29 Å)