8V7H
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8V7E
| Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... | Authors: | Chang, C, Gao, Y. | Deposit date: | 2023-12-04 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ To Be Published
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8V7B
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8V7D
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8V7G
| Human DNA polymerase eta-DNA-gemC-ended primer-dAMPNPP ternary complex with Mg2+ | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(U7B))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... | Authors: | Chang, C, Gao, Y. | Deposit date: | 2023-12-04 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
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8VNU
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7XDK
| Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7054 and BA7125 fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA7054 fab, ... | Authors: | Liu, Z, Lui, S, Gao, Y. | Deposit date: | 2022-03-27 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov, 9, 2023
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7Y3E
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7X2U
| Structure of a human NHE3-CHP1 complex in the autoinhibited state | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Calcineurin B homologous protein 1, Sodium/hydrogen exchanger 3, ... | Authors: | Dong, Y, Li, H, Gao, Y, Zhang, X.C, Zhao, Y. | Deposit date: | 2022-02-26 | Release date: | 2022-04-20 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human NHE3-CHP1 complex in the autoinhibited state Sci Adv, 2022
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7CXM
| Architecture of a SARS-CoV-2 mini replication and transcription complex | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | Deposit date: | 2020-09-02 | Release date: | 2020-11-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
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7D5I
| Structure of Mycobacterium smegmatis bd complex in the apo-form. | Descriptor: | CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Cytochrome D ubiquinol oxidase subunit 1, HEME B/C, ... | Authors: | Wang, W, Gong, H, Gao, Y, Zhou, X, Rao, Z. | Deposit date: | 2020-09-26 | Release date: | 2021-06-23 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Nat Commun, 12, 2021
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7DSV
| Structure of a human NHE1-CHP1 complex under pH 6.5 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Calcineurin B homologous protein 1, Sodium/hydrogen exchanger 1 | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
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7DSW
| Structure of a human NHE1-CHP1 complex under pH 7.5 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Sodium/hydrogen exchanger 1 | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
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7DSX
| Structure of a human NHE1-CHP1 complex under pH 7.5, bound by cariporide | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Calcineurin B homologous protein 1, N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide, ... | Authors: | Dong, Y, Gao, Y, Li, B, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-01-03 | Release date: | 2021-06-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and mechanism of the human NHE1-CHP1 complex. Nat Commun, 12, 2021
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7CXN
| Architecture of a SARS-CoV-2 mini replication and transcription complex | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | Deposit date: | 2020-09-02 | Release date: | 2020-11-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
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7E1V
| Cryo-EM structure of apo hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, CARDIOLIPIN, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-13 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1X
| Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47 | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1W
| Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in the presence of Q203 | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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8TAZ
| Cryo-EM structure of mink variant Y453F trimeric spike protein bound to one mink ACE2 receptors | Descriptor: | Angiotensin-converting enzyme, Spike glycoprotein | Authors: | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Liang, B. | Deposit date: | 2023-06-28 | Release date: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2. J Med Virol, 95, 2023
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8HUD
| Cryo-EM structure of the EvCas9-sgRNA-target DNA ternary complex | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target DNA strand, Target DNA strand, ... | Authors: | Tang, N, Wu, Z, Gao, Y, Chen, W, Su, M, Wang, Z, Ji, Q. | Deposit date: | 2022-12-23 | Release date: | 2023-12-27 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Molecular Basis and Genome Editing Applications of a Compact Eubacterium ventriosum CRISPR-Cas9 System. Acs Synth Biol, 13, 2024
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7W72
| Structure of a human glycosylphosphatidylinositol (GPI) transamidase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GPI transamidase component PIG-S, ... | Authors: | Zhang, H, Su, J, Li, B, Gao, Y, Zhang, X.C, Zhao, Y. | Deposit date: | 2021-12-02 | Release date: | 2022-02-16 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of human glycosylphosphatidylinositol transamidase. Nat.Struct.Mol.Biol., 29, 2022
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7WS2
| Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | Descriptor: | 510A5 heavy chain, 510A5 light chain, Spike protein S1 | Authors: | Guo, H, Gao, Y, Ji, X, Yang, H. | Deposit date: | 2022-01-28 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep, 39, 2022
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7WS8
| Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | Authors: | Guo, H, Gao, Y, Ji, X, Yang, H. | Deposit date: | 2022-01-28 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep, 39, 2022
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7WS6
| Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | Descriptor: | 510A5 heavy chain, 510A5 light chain, Spike protein S1 | Authors: | Guo, H, Gao, Y, Ji, X, Yang, H. | Deposit date: | 2022-01-28 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep, 39, 2022
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7WSA
| Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1 | Authors: | Guo, H, Gao, Y, Ji, X, Yang, H. | Deposit date: | 2022-01-28 | Release date: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of Omicron spike complexes and implications for neutralizing antibody development. Cell Rep, 39, 2022
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