6NB9
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![BU of 6nb9 by Molmil](/molmil-images/mine/6nb9) | Amyloid-Beta (20-34) with L-isoaspartate 23 | Descriptor: | Amyloid-beta A4 protein | Authors: | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | Deposit date: | 2018-12-06 | Release date: | 2019-08-07 | Last modified: | 2022-09-07 | Method: | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | Cite: | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
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1FXU
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![BU of 1fxu by Molmil](/molmil-images/mine/1fxu) | PURINE NUCLEOSIDE PHOSPHORYLASE FROM CALF SPLEEN IN COMPLEX WITH N(7)-ACYCLOGUANOSINE INHIBITOR AND A PHOSPHATE ION | Descriptor: | 2-AMINO-7-[2-(2-HYDROXY-1-HYDROXYMETHYL-ETHYLAMINO)-ETHYL]-1,7-DIHYDRO-PURIN-6-ONE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Luic, M, Bzowska, A, Shugar, D, Saenger, W, Koellner, G. | Deposit date: | 2000-09-27 | Release date: | 2000-10-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion. Acta Crystallogr.,Sect.D, 57, 2001
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6NIY
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![BU of 6niy by Molmil](/molmil-images/mine/6niy) | A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | Descriptor: | Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M. | Deposit date: | 2019-01-02 | Release date: | 2019-01-23 | Last modified: | 2020-04-08 | Method: | ELECTRON MICROSCOPY (3.34 Å) | Cite: | The Molecular Control of Calcitonin Receptor Signaling. Acs Pharmacol Transl Sci, 2, 2019
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5MV4
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![BU of 5mv4 by Molmil](/molmil-images/mine/5mv4) | ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) | Descriptor: | ACC1 antibody Fab fragment, heavy chain, light chain, ... | Authors: | Dobritzsch, D, Holmdahl, R, Ge, C. | Deposit date: | 2017-01-15 | Release date: | 2017-07-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight, 2, 2017
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1GAL
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![BU of 1gal by Molmil](/molmil-images/mine/1gal) | CRYSTAL STRUCTURE OF GLUCOSE OXIDASE FROM ASPERGILLUS NIGER: REFINED AT 2.3 ANGSTROMS RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, GLUCOSE OXIDASE, ... | Authors: | Hecht, H.J, Kalisz, K, Hendle, J, Schmid, R.D, Schomburg, D. | Deposit date: | 1992-08-27 | Release date: | 1993-10-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of glucose oxidase from Aspergillus niger refined at 2.3 A resolution. J.Mol.Biol., 229, 1993
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3ZUF
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7K4P
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![BU of 7k4p by Molmil](/molmil-images/mine/7k4p) | Crystal structure of Kemp Eliminase HG3 | Descriptor: | Endo-1,4-beta-xylanase | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4S
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![BU of 7k4s by Molmil](/molmil-images/mine/7k4s) | Crystal structure of Kemp Eliminase HG3.7 | Descriptor: | Endo-1,4-beta-xylanase, SULFATE ION | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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6NTS
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![BU of 6nts by Molmil](/molmil-images/mine/6nts) | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | Descriptor: | MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ... | Authors: | Huang, W, Taylor, D. | Deposit date: | 2019-01-30 | Release date: | 2020-05-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181, 2020
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5MU2
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![BU of 5mu2 by Molmil](/molmil-images/mine/5mu2) | ACC1 Fab fragment in complex with CII583-591 (CG10) | Descriptor: | ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, synthetic peptide containing the CII583-591 epitope of collagen type II | Authors: | Dobritzsch, D, Holmdahl, R, Ge, C. | Deposit date: | 2017-01-12 | Release date: | 2017-07-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight, 2, 2017
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7B5F
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![BU of 7b5f by Molmil](/molmil-images/mine/7b5f) | Structure of echovirus 18 in complex with neonatal Fc receptor | Descriptor: | Beta-2-microglobulin, Echovirus 18 viral protein 1, Echovirus 18 viral protein 2, ... | Authors: | Buchta, D, Levdansky, Y, Fuzik, T, Mukhamedova, L, Moravcova, J, Hrebik, D, Andersen, J.T, Plevka, P. | Deposit date: | 2020-12-03 | Release date: | 2022-01-12 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of echovirus 18 in complex with neonatal Fc receptor To Be Published
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3ZJK
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![BU of 3zjk by Molmil](/molmil-images/mine/3zjk) | crystal structure of Ttb-gly F401S mutant | Descriptor: | BETA GLYCOSIDASE, CHLORIDE ION, GLYCEROL | Authors: | Teze, D, Tran, V, Tellier, C, Dion, M, Leroux, C, Roncza, J, Czjzek, M. | Deposit date: | 2013-01-18 | Release date: | 2013-02-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Semi-Rational Approach for Converting a Gh1 Beta-Glycosidase Into a Beta-Transglycosidase. Protein Eng.Des.Sel., 27, 2014
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3ZUJ
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![BU of 3zuj by Molmil](/molmil-images/mine/3zuj) | Padron on (fluorescent) ABcis | Descriptor: | FLUORESCENT PROTEIN DRONPA | Authors: | REGIS Faro, A, Carpentier, P, Bourgeois, D. | Deposit date: | 2011-07-19 | Release date: | 2011-08-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.345 Å) | Cite: | Low-Temperature Chromophore Isomerization Reveals the Photoswitching Mechanism of the Fluorescent Protein Padron. J.Am.Chem.Soc., 133, 2011
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1GKP
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![BU of 1gkp by Molmil](/molmil-images/mine/1gkp) | D-Hydantoinase (Dihydropyrimidinase) from Thermus sp. in space group C2221 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HYDANTOINASE, SULFATE ION, ... | Authors: | Abendroth, J, Niefind, K, Schomburg, D. | Deposit date: | 2001-08-20 | Release date: | 2002-06-27 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.295 Å) | Cite: | X-Ray Structure of a Dihydropyrimidinase from Thermus Sp. At 1.3 A Resolution J.Mol.Biol., 320, 2002
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6NJJ
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![BU of 6njj by Molmil](/molmil-images/mine/6njj) | Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN14770 | Descriptor: | (4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Fox III, D, Fairman, J.W, Gurney, M.E. | Deposit date: | 2019-01-03 | Release date: | 2019-05-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J.Med.Chem., 62, 2019
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4AK9
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![BU of 4ak9 by Molmil](/molmil-images/mine/4ak9) | |
5N1V
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![BU of 5n1v by Molmil](/molmil-images/mine/5n1v) | Crystal structure of the protein kinase CK2 catalytic subunit in complex with pyrazolo-pyrimidine macrocyclic ligand | Descriptor: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | Authors: | Robb, G, Ferguson, A, Hargreaves, D. | Deposit date: | 2017-02-06 | Release date: | 2017-05-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. J. Med. Chem., 60, 2017
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5MVL
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![BU of 5mvl by Molmil](/molmil-images/mine/5mvl) | Crystal structure of an A-DNA dodecamer containing 5-bromouracil | Descriptor: | Brominated DNA dodecamer, MAGNESIUM ION | Authors: | Hardwick, J.S, Ptchelkine, D, Phillips, S.E.V, Brown, T. | Deposit date: | 2017-01-16 | Release date: | 2017-05-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.405 Å) | Cite: | 5-Formylcytosine does not change the global structure of DNA. Nat. Struct. Mol. Biol., 24, 2017
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7K4X
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![BU of 7k4x by Molmil](/molmil-images/mine/7k4x) | Crystal structure of Kemp Eliminase HG3.7 in complex with the transition state analog 6-nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, ACETATE ION, Endo-1,4-beta-xylanase, ... | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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1NIR
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![BU of 1nir by Molmil](/molmil-images/mine/1nir) | OXYDIZED NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA | Descriptor: | CHLORIDE ION, HEME C, HEME D, ... | Authors: | Nurizzo, D, Tegoni, M, Cambillau, C. | Deposit date: | 1997-06-17 | Release date: | 1997-12-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | N-terminal arm exchange is observed in the 2.15 A crystal structure of oxidized nitrite reductase from Pseudomonas aeruginosa. Structure, 5, 1997
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1GG5
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![BU of 1gg5 by Molmil](/molmil-images/mine/1gg5) | CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION | Descriptor: | 3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL, FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)H DEHYDROGENASE [QUINONE] 1 | Authors: | Faig, M, Bianchet, M.A, Winski, S, Hargreaves, R, Moody, C.J, Hudnott, A.R, Ross, D, Amzel, L.M. | Deposit date: | 2000-07-12 | Release date: | 2001-09-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Structure, 9, 2001
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7K4Z
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![BU of 7k4z by Molmil](/molmil-images/mine/7k4z) | Crystal structure of Kemp Eliminase HG3.17 in complex with the transition state analog 6-nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, PENTAETHYLENE GLYCOL | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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1FVO
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![BU of 1fvo by Molmil](/molmil-images/mine/1fvo) | CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASE COMPLEXED WITH CARBAMOYL PHOSPHATE | Descriptor: | ORNITHINE TRANSCARBAMYLASE, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER | Authors: | Shi, D, Morizono, H, Yu, X, Allewell, N.M, Tuchman, M. | Deposit date: | 2000-09-20 | Release date: | 2001-04-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes. Biochem.J., 354, 2001
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7K4Q
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![BU of 7k4q by Molmil](/molmil-images/mine/7k4q) | Crystal structure of Kemp Eliminase HG3 in complex with the transition state analog 6-nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, SULFATE ION | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4V
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![BU of 7k4v by Molmil](/molmil-images/mine/7k4v) | Crystal structure of Kemp Eliminase HG3.17 | Descriptor: | Endo-1,4-beta-xylanase, TETRAETHYLENE GLYCOL | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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