4ZCW

Structure of Human Enolase 2 in complex with SF2312

Summary for 4ZCW

Entry DOI	10.2210/pdb4zcw/pdb
Related	4ZA0
Descriptor	Gamma-enolase, [(3S,5S)-1,5-dihydroxy-2-oxopyrrolidin-3-yl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	enolase gamma, glycolysis, neuron specific enolase, inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P09104
Total number of polymer chains	2
Total formula weight	96789.93
Authors	Leonard, P.G.,Maxwell, D.,Czako, B.,Muller, F.L. (deposition date: 2015-04-16, release date: 2016-07-20, Last modification date: 2023-09-27)
Primary citation	Leonard, P.G.,Satani, N.,Maxwell, D.,Lin, Y.H.,Hammoudi, N.,Peng, Z.,Pisaneschi, F.,Link, T.M.,Lee, G.R.,Sun, D.,Prasad, B.A.,Di Francesco, M.E.,Czako, B.,Asara, J.M.,Wang, Y.A.,Bornmann, W.,DePinho, R.A.,Muller, F.L. SF2312 is a natural phosphonate inhibitor of enolase. Nat.Chem.Biol., 12:1053-1058, 2016 Cited by PubMed: 27723749 DOI: 10.1038/nchembio.2195 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.992 Å)

Structure validation