1A3E

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2

Summary for 1A3E

DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ... (5 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space P00734 P00734
Secreted P28504
Total number of polymer chains3
Total molecular weight36530.92
Authors
Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scullly, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J. (deposition date: 1998-01-21, release date: 1998-06-03, Last modification date: 2011-07-13)
Primary citation
Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scully, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J.J.
Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37:14420-14427, 1998
PubMed: 9772168 (PDB entries with the same primary citation)
DOI: 10.1021/bi980225a
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers60.4%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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