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1WC1
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BU of 1wc1 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS
Descriptor: ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ADENYLATE CYCLASE, MAGNESIUM ION
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-06
Release date:2004-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
1WC4
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BU of 1wc4 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Europium
Descriptor: ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, EUROPIUM (III) ION
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-08
Release date:2004-12-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
1WC0
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BU of 1wc0 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP
Descriptor: ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-05
Release date:2004-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
6MJ2
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BU of 6mj2 by Molmil
Human TRPM2 ion channel in a calcium- and ADPR-bound state
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 2
Authors:Wang, L, Fu, T.M, Xia, S, Wu, H.
Deposit date:2018-09-20
Release date:2018-12-12
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (6.36 Å)
Cite:Structures and gating mechanism of human TRPM2.
Science, 362, 2018
6MIX
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BU of 6mix by Molmil
Human TRPM2 ion channel in apo state
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Wang, L, Fu, T.M, Xia, S, Wu, H.
Deposit date:2018-09-20
Release date:2018-12-12
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures and gating mechanism of human TRPM2.
Science, 362, 2018
1WC3
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BU of 1wc3 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Strontium
Descriptor: ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, STRONTIUM ION
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-08
Release date:2004-12-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
1WC5
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BU of 1wc5 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP in presence of bicarbonate
Descriptor: ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-08
Release date:2004-12-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
1WC6
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BU of 1wc6 by Molmil
Soluble adenylyl cyclase CyaC from S. platensis in complex with Rp- ATPalphaS in presence of bicarbonate
Descriptor: ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ADENYLATE CYCLASE, MAGNESIUM ION
Authors:Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H.
Deposit date:2004-11-08
Release date:2004-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
Nat.Struct.Mol.Biol., 12, 2005
5U4X
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BU of 5u4x by Molmil
Coactivator-associated arginine methyltransferase 1 with TP-064
Descriptor: Histone-arginine methyltransferase CARM1, N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:DONG, A, ZENG, H, Saikatendu, K.S, STONE, H, WALKER, J.R, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-12-06
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Oncotarget, 9, 2018
6MIZ
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BU of 6miz by Molmil
Human TRPM2 ion channel in an ADPR-bound state
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Wang, L, Fu, T.M, Xia, S, Wu, H.
Deposit date:2018-09-20
Release date:2018-12-12
Last modified:2019-01-02
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structures and gating mechanism of human TRPM2.
Science, 362, 2018
6N1H
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BU of 6n1h by Molmil
Cryo-EM structure of ASC-CARD filament
Descriptor: Apoptosis-associated speck-like protein containing a CARD
Authors:Li, Y, Fu, T, Wu, H.
Deposit date:2018-11-08
Release date:2018-12-05
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3SMT
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BU of 3smt by Molmil
Crystal structure of human SET domain-containing protein3
Descriptor: ACETATE ION, ARSENIC, Histone-lysine N-methyltransferase setd3, ...
Authors:Dong, A, Zeng, H, Walker, J.R, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of human SET domain-containing protein3
To be Published
6NCV
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BU of 6ncv by Molmil
Cryo-EM structure of NLRP6 PYD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 6
Authors:Shen, C, Fu, T.M, Wu, H.
Deposit date:2018-12-12
Release date:2019-01-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NDJ
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BU of 6ndj by Molmil
Crystal structure of human NLRP6 PYD domain with MBP fusion
Descriptor: Maltose/maltodextrin-binding periplasmic protein, NACHT, LRR and PYD domains-containing protein 6 chimera
Authors:Shen, C, Fu, T.M, Wu, H.
Deposit date:2018-12-13
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1Y2Y
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BU of 1y2y by Molmil
Structural Characterization of Nop10p using Nuclear Magnetic Resonance Spectroscopy
Descriptor: Ribosome biogenesis protein Nop10
Authors:Khanna, M, Wu, H, Johansson, C, Caizergues-Ferrer, M, Feigon, J.
Deposit date:2004-11-23
Release date:2005-12-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA
RNA, 12, 2006
4JLG
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BU of 4jlg by Molmil
SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine
Descriptor: 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ...
Authors:Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-03-12
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
6N1I
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BU of 6n1i by Molmil
Cryo-EM structure of NLRC4-CARD filament
Descriptor: NLR family CARD domain-containing protein 4
Authors:Li, Y, Fu, T, Wu, H.
Deposit date:2018-11-08
Release date:2018-12-05
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MK7
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BU of 6mk7 by Molmil
Solution structure of the large extracellular loop of FtsX in Streptococcus pneumoniae
Descriptor: Cell division protein FtsX
Authors:Edmonds, K.A, Fu, Y, Wu, H, Rued, B.E, Bruce, K.E, Winkler, M.E, Giedroc, D.P.
Deposit date:2018-09-25
Release date:2019-02-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae.
MBio, 10, 2019
5EGS
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BU of 5egs by Molmil
Human PRMT6 with bound fragment-type inhibitor
Descriptor: 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine, Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Steuber, H, Egner, U, Kania, J, Wu, H, Brown, P.J.
Deposit date:2015-10-27
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
J.Med.Chem., 59, 2016
4H12
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BU of 4h12 by Molmil
The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-09-10
Release date:2012-10-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
6NHW
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BU of 6nhw by Molmil
Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer
Descriptor: Tumor necrosis factor receptor superfamily member 10B
Authors:Chou, J.J, Pan, L, Fu, Q, Zhao, L, Chen, W, Piai, A, Fu, T, Wu, H.
Deposit date:2018-12-24
Release date:2019-02-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
6NHY
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BU of 6nhy by Molmil
Structure of the transmembrane domain of the Death Receptor 5 mutant (G217Y) - Trimer Only
Descriptor: Tumor necrosis factor receptor superfamily member 10B
Authors:Chou, J.J, Pan, L, Zhao, L, Chen, W, Piai, A, Fu, T, Wu, H, Liu, Z.
Deposit date:2018-12-24
Release date:2019-02-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
Cell, 176, 2019
1XRK
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BU of 1xrk by Molmil
Crystal structure of a mutant bleomycin binding protein from Streptoalloteichus hindustanus displaying increased thermostability
Descriptor: BLEOMYCIN A2, Bleomycin resistance protein, SULFATE ION
Authors:Brouns, S.J.J, Wu, H, Akerboom, J, Turnbull, A.P, de Vos, W.M, Van der Oost, J.
Deposit date:2004-10-15
Release date:2005-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Engineering a selectable marker for hyperthermophiles
J.Biol.Chem., 280, 2005
5FAI
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BU of 5fai by Molmil
EMG1 N1-Specific Pseudouridine Methyltransferase
Descriptor: CITRIC ACID, Ribosomal RNA small subunit methyltransferase NEP1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:DONG, A, ZENG, H, LI, Y, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2015-12-11
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:EMG1 N1-Specific Pseudouridine Methyltransferase
to be published
5HEA
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BU of 5hea by Molmil
CgT structure in hexamer
Descriptor: Putative glycosyltransferase (GalT1)
Authors:Zhang, H, Wu, H.
Deposit date:2016-01-05
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A new helical binding domain mediates a glycosyltransferase activity of a bifunctional protein
To Be Published

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PDB entries from 2024-07-17

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