6N1H

Cryo-EM structure of ASC-CARD filament

Replaces:  6DRN

Summary for 6N1H

• Entry DOI: 10.2210/pdb6n1h/pdb
• EMDB information: 8902 8903
• Descriptor: Apoptosis-associated speck-like protein containing a CARD (1 entity in total)
• Functional Keywords: inflammasome, filament, immunity, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 156402.29

Authors

Li, Y.,Fu, T.,Wu, H. (deposition date: 2018-11-08, release date: 2018-12-05, Last modification date: 2024-03-13)

• Primary citation: Li, Y.,Fu, T.M.,Lu, A.,Witt, K.,Ruan, J.,Shen, C.,Wu, H.; Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.; Proc. Natl. Acad. Sci. U.S.A., 115:10845-10852, 2018; PubMed: 30279182; DOI: 10.1073/pnas.1810524115

Experimental method

ELECTRON MICROSCOPY (3.17 Å)