6N1I

Cryo-EM structure of NLRC4-CARD filament

Replaces:  6DRP

Summary for 6N1I

• Entry DOI: 10.2210/pdb6n1i/pdb
• EMDB information: 8902 8903
• Descriptor: NLR family CARD domain-containing protein 4 (1 entity in total)
• Functional Keywords: inflammasome, filament, immunity, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 159802.74

Authors

Li, Y.,Fu, T.,Wu, H. (deposition date: 2018-11-08, release date: 2018-12-05, Last modification date: 2024-03-13)

• Primary citation: Li, Y.,Fu, T.M.,Lu, A.,Witt, K.,Ruan, J.,Shen, C.,Wu, H.; Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1.; Proc. Natl. Acad. Sci. U.S.A., 115:10845-10852, 2018; PubMed: 30279182; DOI: 10.1073/pnas.1810524115

Experimental method

ELECTRON MICROSCOPY (3.58 Å)