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8PSX
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BU of 8psx by Molmil
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PT6
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BU of 8pt6 by Molmil
Tilapia Lake Virus polymerase in vRNA initiation state (replicase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), DNA (5'-D(*(CTP))-3'), MAGNESIUM ION, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSZ
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BU of 8psz by Molmil
Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
2C6S
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BU of 2c6s by Molmil
human adenovirus penton base 2 12 chimera
Descriptor: ADENOVIRUS 2,12 PENTON BASE CHIMERA
Authors:Zubieta, C, Blanchoin, L, Cusack, S.
Deposit date:2005-11-11
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural and Biochemical Characterization of a Human Adenovirus 2/12 Penton Base Chimera.
FEBS J., 273, 2006
8QZ8
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BU of 8qz8 by Molmil
Tilapia Lake Virus polymerase in vRNA pre-termination state (transcriptase conformation)
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-10-26
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
5AMQ
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BU of 5amq by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell, 161, 2015
5AMR
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BU of 5amr by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell(Cambridge,Mass.), 161, 2015
2I4L
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BU of 2i4l by Molmil
Rhodopseudomonas palustris prolyl-tRNA synthetase
Descriptor: Proline-tRNA ligase
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4N
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BU of 2i4n by Molmil
Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with CysAMS
Descriptor: 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Proline-tRNA ligase
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
2I4M
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BU of 2i4m by Molmil
Rhodopseudomonas palustris prolyl-tRNA synthetase in complex with ProAMS
Descriptor: '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, Proline-tRNA ligase
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain.
Structure, 14, 2006
1H7Z
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BU of 1h7z by Molmil
Adenovirus Ad3 fibre head
Descriptor: ADENOVIRUS FIBRE PROTEIN, SULFATE ION
Authors:Durmort, C, Stehlin, C, Schoehn, G, Mitraki, A, Drouet, E, Cusack, S, Burmeister, W.P.
Deposit date:2001-01-21
Release date:2001-07-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the Fiber Head of Ad3, a Non-Car-Binding Serotype of Adenovirus
Virology, 285, 2001
1H6K
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BU of 1h6k by Molmil
nuclear Cap Binding Complex
Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, CBP80
Authors:Mazza, C, Ohno, M, Segref, A, Mattaj, I.W, Cusack, S.
Deposit date:2001-06-18
Release date:2001-09-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human Nuclear CAP Binding Complex
Mol.Cell, 8, 2001
2J3M
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BU of 2j3m by Molmil
PROLYL-TRNA SYNTHETASE FROM ENTEROCOCCUS FAECALIS COMPLEXED WITH ATP, manganese and prolinol
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PROLYL-TRNA SYNTHETASE, ...
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a Cis-Editing Domain.
Structure, 14, 2006
2J3L
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BU of 2j3l by Molmil
Prolyl-tRNA synthetase from Enterococcus faecalis complexed with a prolyl-adenylate analogue ('5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE)
Descriptor: '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, PROLYL-TRNA SYNTHETASE, SULFATE ION
Authors:Crepin, T, Yaremchuk, A, Tukalo, M, Cusack, S.
Deposit date:2006-08-22
Release date:2006-10-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a Cis-Editing Domain.
Structure, 14, 2006
2J2J
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BU of 2j2j by Molmil
Canine adenovirus fibre head at 1.5 A resolution
Descriptor: FIBER PROTEIN
Authors:Seiradake, E, Lortat-Jacob, H, Billet, O, Kremer, E.J, Cusack, S.
Deposit date:2006-08-16
Release date:2006-09-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor.
J.Biol.Chem., 281, 2006
2J1K
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BU of 2j1k by Molmil
CAV-2 fibre head in complex with CAR D1
Descriptor: COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR, FIBER PROTEIN
Authors:Seiradake, E, Lortat-Jacob, H, Billet, O, Kremer, E.J, Cusack, S.
Deposit date:2006-08-14
Release date:2006-09-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor.
J.Biol.Chem., 281, 2006
5OMW
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BU of 5omw by Molmil
Mutant T252A of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue in the aminoacylation conformation
Descriptor: 5'-O-(L-leucylsulfamoyl)adenosine, L-leucyl-tRNA, Leucine--tRNA ligase, ...
Authors:Palencia, A, Cusack, S.
Deposit date:2017-08-02
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ONH
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BU of 5onh by Molmil
Quaternary complex of wild type E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation
Descriptor: 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, L-leucyl-tRNA(Leu), ...
Authors:Palencia, A, Cusack, S.
Deposit date:2017-08-03
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ON2
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BU of 5on2 by Molmil
Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of norvaline in the aminoacylation conformation
Descriptor: 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ...
Authors:Palencia, A, Cusack, S.
Deposit date:2017-08-02
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
5ON3
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BU of 5on3 by Molmil
Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu), leucyl-adenylate analogue, and post-transfer editing analogue of leucine in the aminoacylation conformation
Descriptor: (2~{S})-~{N}-[(2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]-2-azanyl-4-methyl-pentanamide, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ...
Authors:Palencia, A, Cusack, S.
Deposit date:2017-08-02
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase.
J. Mol. Biol., 430, 2018
2IYK
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BU of 2iyk by Molmil
Crystal structure of the UPF2-interacting domain of nonsense mediated mRNA decay factor UPF1
Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 1, ZINC ION
Authors:Kadlec, J, Guilligay, D, Ravelli, R.B, Cusack, S.
Deposit date:2006-07-18
Release date:2006-08-30
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal Structure of the Upf2-Interacting Domain of Nonsense-Mediated Mrna Decay Factor Upf1.
RNA, 12, 2006
2J12
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BU of 2j12 by Molmil
Ad37 fibre head in complex with CAR D1
Descriptor: CALCIUM ION, COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR, FIBER PROTEIN
Authors:Seiradake, E, Lortat-Jacob, H, Billet, O, Kremer, E.J, Cusack, S.
Deposit date:2006-08-08
Release date:2006-08-29
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor.
J.Biol.Chem., 281, 2006
4CB7
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BU of 4cb7 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e)
Descriptor: 5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid, GLYCEROL, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
4CB5
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BU of 4cb5 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)
Descriptor: 9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE, CHLORIDE ION, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
4CB6
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Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11)
Descriptor: 2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE, IODIDE ION, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013

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