4CB6
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11)
Summary for 4CB6
Entry DOI | 10.2210/pdb4cb6/pdb |
Related | 4CB4 4CB5 4CB7 |
Descriptor | POLYMERASE BASIC SUBUNIT 2, 2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE, IODIDE ION, ... (4 entities in total) |
Functional Keywords | transferase, influenza polymerase, m7gtp, cap-binding inhibitors |
Biological source | INFLUENZA A VIRUS |
Total number of polymer chains | 2 |
Total formula weight | 40158.44 |
Authors | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20) |
Primary citation | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208DOI: 10.1021/JM401369Y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report