4CB5

Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)

Summary for 4CB5

Entry DOI	10.2210/pdb4cb5/pdb
Related	4CB4
Descriptor	POLYMERASE BASIC SUBUNIT 2, 9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	transferase, cap-binding inhibitors
Biological source	Influenza A virus (A/duck/Shantou/4610/2003(H5N1))
Cellular location	Host nucleus : Q2LG68
Total number of polymer chains	1
Total formula weight	19337.63
Authors	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citation	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208 DOI: 10.1021/JM401369Y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation