6M7M
| rac-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | L-GSTSTA from ice nucleation protein, inaZ, and its enantiomer, ... | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-20 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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6M9J
| Racemic-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712 | Descriptor: | Ice nucleation protein | Authors: | Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2018-08-23 | Release date: | 2019-03-27 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | Cite: | Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ, 6, 2019
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6N3C
| SegB, conformation of TDP-43 low complexity domain segment A | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N3B
| SegA-asym, conformation of TDP-43 low complexity domain segment A asym | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N3A
| SegA-long, conformation of TDP-43 low complexity domain segment A long | Descriptor: | TAR DNA-binding protein 43, segA long small | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6N37
| SegA-sym, conformation of TDP-43 low complexity domain segment A sym | Descriptor: | TAR DNA-binding protein 43 | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2018-11-14 | Release date: | 2019-06-26 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat.Struct.Mol.Biol., 26, 2019
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6NK4
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6WPQ
| GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | Descriptor: | Heterogeneous nuclear ribonucleoprotein A2 | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-27 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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6X1I
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7QYD
| mosquitocidal Cry11Ba determined at pH 6.5 from naturally-occurring nanocrystals by Serial femtosecond crystallography | Descriptor: | Pesticidal crystal protein Cry11Ba | Authors: | De Zitter, E, Tetreau, G, Andreeva, E.A, Coquelle, N, Colletier, J.-P, Sawaya, M.R, Schibrowsky, N.A, Cascio, D, Rodriguez, J.A. | Deposit date: | 2022-01-28 | Release date: | 2022-07-27 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. Nat Commun, 13, 2022
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6XPH
| CutR dimer with domain swap | Descriptor: | Ethanolamine utilization protein EutS, GLYCEROL, POTASSIUM ION, ... | Authors: | Ochoa, J.M, Sawaya, M.R, Nguyen, V.N, Duilio, C, Yeates, T.O, Nie, M. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. Protein Sci., 29, 2020
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6XPL
| CutR Screw, form 2 with 33.8 angstrom pitch | Descriptor: | Ethanolamine utilization protein EutS | Authors: | Ochoa, J.M, Sawaya, M.R, Nguyen, V.N, Duilio, C, Yeates, T.O. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. Protein Sci., 29, 2020
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6XPI
| CutR flat hexamer, form 1 | Descriptor: | Ethanolamine utilization protein EutS | Authors: | Ochoa, J.M, Sawaya, M.R, Nguyen, V.N, Duilio, C, Yeates, T.O. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. Protein Sci., 29, 2020
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6XPJ
| CutR flat hexamer, form 2 | Descriptor: | Ethanolamine utilization protein EutS, SULFATE ION | Authors: | Ochoa, J.M, Sawaya, M.R, Nguyen, V.N, Duilio, C, Yeates, T.O. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. Protein Sci., 29, 2020
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6WQK
| hnRNPA2 Low complexity domain (LCD) determined by cryoEM | Descriptor: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-29 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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7R1E
| Mosquitocidal Cry11Ba determined at pH 10.4 from naturally-occurring nanocrystals by Serial femtosecond crystallography | Descriptor: | GLYCEROL, Pesticidal crystal protein Cry11Ba | Authors: | Colletier, J.-P, Sawaya, M.R, Schibrowsky, N.A, Cascio, D, Rodriguez, J.A. | Deposit date: | 2022-02-02 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. Nat Commun, 13, 2022
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6XPK
| CutR Screw, form 1 with 41.9 angstrom pitch | Descriptor: | Ethanolamine utilization protein EutS | Authors: | Ochoa, J.M, Sawaya, M.R, Nguyen, V.N, Duilio, C, Yeates, T.O. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Symmetry breaking and structural polymorphism in a bacterial microcompartment shell protein for choline utilization. Protein Sci., 29, 2020
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7SAS
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAQ
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAR
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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1NOM
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6ODG
| SVQIVY, Crystal Structure of a tau protein fragment | Descriptor: | Microtubule-associated protein tau | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | Deposit date: | 2019-03-26 | Release date: | 2019-10-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J.Biol.Chem., 294, 2019
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6PES
| Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | Descriptor: | Alpha-synuclein | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | Deposit date: | 2019-06-20 | Release date: | 2019-11-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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6PIL
| Antibody scFv-M204 monomeric state | Descriptor: | CHLORIDE ION, scFv-M204 antibody | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | Deposit date: | 2019-06-26 | Release date: | 2020-06-24 | Last modified: | 2020-08-12 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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6O4J
| Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation | Descriptor: | Amyloid-beta precursor protein | Authors: | Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T. | Deposit date: | 2019-02-28 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | Cite: | Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife, 8, 2019
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