8R10

Pim1 in complex with 4-(4-hydroxystyryl)benzoic acid and Pimtide

8R10 の概要

• エントリーDOI: 10.2210/pdb8r10/pdb
• 関連するPDBエントリー: 7QB2 7QFM 7Z6U 8AFR 8R0H 8R0Q 8R0W 8R0Y
• 分子名称: Serine/threonine-protein kinase pim-1, Pimtide, (Z)-4-(4-hydroxystyryl)benzoic acid, ... (4 entities in total)
• 機能のキーワード: serine kinase, kinase, complex, pim1, pim, pim-1, inhibitor, tumorigenisis, cancer, pimtide, proto oncogen, atp, phosphorylation, apoptosis, cell cycle, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37503.58

構造登録者

Hochban, P.M.M.,Heine, A.,Diederich, W.E. (登録日: 2023-11-01, 公開日: 2024-03-20, 最終更新日: 2024-06-12)

• 主引用文献: Hochban, P.M.M.,Heyder, L.,Heine, A.,Diederich, W.E.; What doesn't fit is made to fit: Pim-1 kinase adapts to the configuration of stilbene-based inhibitors.; Arch Pharm, 357:e2400094-e2400094, 2024; PubMed: 38631036; DOI: 10.1002/ardp.202400094

実験手法

X-RAY DIFFRACTION (2.2 Å)