8AFR
Pim1 in complex with 4-((6-hydroxybenzofuran-3-yl)methyl)benzoic acid and Pimtide
Summary for 8AFR
Entry DOI | 10.2210/pdb8afr/pdb |
Related | 7QB2 7QFM 7Z6U |
Descriptor | Serine/threonine-protein kinase pim-1, Pimtide, 4-((6-hydroxybenzofuran-3-yl)methyl)benzoic acid, ... (4 entities in total) |
Functional Keywords | serine kinase, kinase, complex, pim1, pim, pim-1, inhibitor, tumorigenisis, cancer, pimtide, proto oncogen, atp, phosphorylation, apoptosis, cell cycle, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 37217.26 |
Authors | Hochban, P.M.M.,Heine, A.,Diederich, W.E. (deposition date: 2022-07-18, release date: 2023-02-01, Last modification date: 2024-02-07) |
Primary citation | Heyder, L.,Hochban, P.M.M.,Taylor, C.,Chevillard, F.,Siefker, C.,Iking, C.,Borchardt, H.,Aigner, A.,Klebe, G.,Heine, A.,Kolb, P.,Diederich, W.E. Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245:114914-114914, 2023 Cited by PubMed: 36410167DOI: 10.1016/j.ejmech.2022.114914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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