7QB2
Pim1 in complex with (E)-4-((6-amino-1-methyl-2-oxoindolin-3-ylidene)methyl)benzoic acid and Pimtide
Summary for 7QB2
Entry DOI | 10.2210/pdb7qb2/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, Pimtide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | serine kinase, kinase, complex, pim1, pim, pim-1, inhibitor, tumorigenisis, cancer, pimtide, proto oncogen, atp, phosphorylation, apoptosis, cell cycle, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 37562.65 |
Authors | Hochban, P.M.M.,Heine, A.,Diederich, W.E. (deposition date: 2021-11-18, release date: 2022-11-30, Last modification date: 2024-02-07) |
Primary citation | Heyder, L.,Hochban, P.M.M.,Taylor, C.,Chevillard, F.,Siefker, C.,Iking, C.,Borchardt, H.,Aigner, A.,Klebe, G.,Heine, A.,Kolb, P.,Diederich, W.E. Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. Eur.J.Med.Chem., 245:114914-114914, 2023 Cited by PubMed: 36410167DOI: 10.1016/j.ejmech.2022.114914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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