7WL0
Crystal structure of human ALKBH5 in complex with N-oxalylglycine (NOG) and m6A-containing ssRNA
Summary for 7WL0
Entry DOI | 10.2210/pdb7wl0/pdb |
Related | 7V4G 7WKV |
Descriptor | RNA demethylase ALKBH5, RNA (5'-R(*UP*GP*GP*(6MZ)P*CP*UP*GP*C)-3'), MANGANESE (II) ION, ... (6 entities in total) |
Functional Keywords | iron and 2-oxoglutarate dependent oxygenase, rna demethylase, oxidoreductase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 10 |
Total formula weight | 139533.17 |
Authors | Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2022-01-12, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Kaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Res., 50:4148-4160, 2022 Cited by PubMed: 35333330DOI: 10.1093/nar/gkac195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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