7WL0
Crystal structure of human ALKBH5 in complex with N-oxalylglycine (NOG) and m6A-containing ssRNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I (A, C, E, G, I) | RNA demethylase ALKBH5 | polymer | 220 | 25138.8 | 5 | UniProt (Q6P6C2) Pfam (PF13532) | Homo sapiens (human) | Alkylated DNA repair protein alkB homolog 5,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 |
| 2 | B, D, F, H, J (B, D, F, H, J) | RNA (5'-R(*UP*GP*GP*(6MZ)P*CP*UP*GP*C)-3') | polymer | 8 | 2556.6 | 5 | synthetic construct | ||
| 3 | K, M, P, R, T (A, C, E, G, I) | MANGANESE (II) ION | non-polymer | 54.9 | 5 | Chemie (MN) | |||
| 4 | L, N, Q, S, U (A, C, E, G, I) | N-OXALYLGLYCINE | non-polymer | 147.1 | 5 | Chemie (OGA) | |||
| 5 | O (C) | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 6 | AA, BA, CA, DA, EA... (F, G, H, I, J...) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I: 74 - 292 (UniProt: Q6P6C2)
| PDB | External Database | Details |
|---|---|---|
| Ser 73 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 138477.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1056.1 | |
| All* | Total formula weight | 139533.2 |
