7WL0

Crystal structure of human ALKBH5 in complex with N-oxalylglycine (NOG) and m6A-containing ssRNA

Summary for 7WL0

• Entry DOI: 10.2210/pdb7wl0/pdb
• Related: 7V4G 7WKV
• Descriptor: RNA demethylase ALKBH5, RNA (5'-R(*UP*GP*GP*(6MZ)P*CP*UP*GP*C)-3'), MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: iron and 2-oxoglutarate dependent oxygenase, rna demethylase, oxidoreductase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 139533.17

Authors

Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2022-01-12, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Kaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S.; Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.; Nucleic Acids Res., 50:4148-4160, 2022; PubMed: 35333330; DOI: 10.1093/nar/gkac195

Experimental method

X-RAY DIFFRACTION (2.5 Å)