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7WKV

Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing ssRNA

Summary for 7WKV
Entry DOI10.2210/pdb7wkv/pdb
Related7V4G
DescriptorRNA demethylase ALKBH5, RNA (5'-R(P*GP*GP*(6MZ)P*C)-3'), MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordsiron and 2-oxoglutarate dependent oxygenase, rna demethylase, oxidoreductase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna
Biological sourceHomo sapiens (human)
More
Total number of polymer chains6
Total formula weight83689.33
Authors
Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2022-01-11, release date: 2022-03-30, Last modification date: 2023-11-29)
Primary citationKaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S.
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
Nucleic Acids Res., 50:4148-4160, 2022
Cited by
PubMed: 35333330
DOI: 10.1093/nar/gkac195
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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