7WKV
Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing ssRNA
Summary for 7WKV
Entry DOI | 10.2210/pdb7wkv/pdb |
Related | 7V4G |
Descriptor | RNA demethylase ALKBH5, RNA (5'-R(P*GP*GP*(6MZ)P*C)-3'), MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | iron and 2-oxoglutarate dependent oxygenase, rna demethylase, oxidoreductase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 83689.33 |
Authors | Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2022-01-11, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Kaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Res., 50:4148-4160, 2022 Cited by PubMed: 35333330DOI: 10.1093/nar/gkac195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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