7WKV
Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing ssRNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | RNA demethylase ALKBH5 | polymer | 220 | 25138.8 | 3 | UniProt (Q6P6C2) Pfam (PF13532) | Homo sapiens (human) | Alkylated DNA repair protein alkB homolog 5,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 |
| 2 | B, D, F (B, D, F) | RNA (5'-R(P*GP*GP*(6MZ)P*C)-3') | polymer | 8 | 2556.6 | 3 | synthetic construct | ||
| 3 | G, I, K (A, C, E) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 4 | H, J, L (A, C, E) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 3 | Chemie (AKG) | |||
| 5 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A, C, E: 74 - 292 (UniProt: Q6P6C2)
| PDB | External Database | Details |
|---|---|---|
| Ser 73 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 83086.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 603.1 | |
| All* | Total formula weight | 83689.3 |
