7V4G
Crystal structure of human ALKBH5 in complex with m6A-containing ssRNA
Summary for 7V4G
Entry DOI | 10.2210/pdb7v4g/pdb |
Descriptor | RNA (5'-R(P*GP*GP*(6MZ)P*C)-3'), RNA demethylase ALKBH5, GLYCEROL, ... (6 entities in total) |
Functional Keywords | iron and 2-oxoglutarate dependent oxygenase, rna demethylase, double-stranded beta helix, oxidoreductase-rna complex, oxidoreductase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 83907.60 |
Authors | Kaur, S.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. (deposition date: 2021-08-13, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Kaur, S.,Tam, N.Y.,McDonough, M.A.,Schofield, C.J.,Aik, W.S. Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Res., 50:4148-4160, 2022 Cited by PubMed: 35333330DOI: 10.1093/nar/gkac195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report