7V4G
Crystal structure of human ALKBH5 in complex with m6A-containing ssRNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006397 | biological_process | mRNA processing |
| A | 0035515 | molecular_function | oxidative RNA demethylase activity |
| B | 0006397 | biological_process | mRNA processing |
| B | 0035515 | molecular_function | oxidative RNA demethylase activity |
| C | 0006397 | biological_process | mRNA processing |
| C | 0035515 | molecular_function | oxidative RNA demethylase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:35333330 |
| Chain | Residue | Details |
| A | TYR139 | |
| B | TYR139 | |
| C | TYR139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:35333330, ECO:0007744|PDB:4NRO, ECO:0007744|PDB:4OCT, ECO:0007744|PDB:7WKV |
| Chain | Residue | Details |
| A | ASN193 | |
| A | TYR195 | |
| A | ARG277 | |
| B | ASN193 | |
| B | TYR195 | |
| B | ARG277 | |
| C | ASN193 | |
| C | TYR195 | |
| C | ARG277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24616105, ECO:0000305|PubMed:24778178, ECO:0000305|PubMed:35333330, ECO:0007744|PDB:7V4G, ECO:0007744|PDB:7WKV, ECO:0007744|PDB:7WL0 |
| Chain | Residue | Details |
| A | HIS204 | |
| A | ASP206 | |
| A | HIS266 | |
| B | HIS204 | |
| B | ASP206 | |
| B | HIS266 | |
| C | HIS204 | |
| C | ASP206 | |
| C | HIS266 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000269|PubMed:34048572 |
| Chain | Residue | Details |
| A | SER87 | |
| B | SER87 | |
| C | SER87 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS132 | |
| B | LYS132 | |
| C | LYS132 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:37369679 |
| Chain | Residue | Details |
| A | LYS235 | |
| B | LYS235 | |
| C | LYS235 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:34048572 |
| Chain | Residue | Details |
| A | LYS86 | |
| B | LYS86 | |
| C | LYS86 |
