5M71

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with an (R)-methyl substitued Fasudil-derivative.

5M71 の概要

• エントリーDOI: 10.2210/pdb5m71/pdb
• 関連するPDBエントリー: 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V 5M6Y
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[[(2~{R})-2-methyl-1,4-diazepan-4-ium-1-yl]sulfonyl]isoquinoline, ... (5 entities in total)
• 機能のキーワード: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43678.62

構造登録者

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2016-10-26, 公開日: 2018-06-06, 最終更新日: 2024-01-17)

• 主引用文献: Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with differently methylated Fasudil-derived ligands; To be Published,

実験手法

X-RAY DIFFRACTION (1.488 Å)