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5M0B

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a short-chained N-(2-aminoethyl)isoquinoline-5-sulfonamide) Fasudil-derivative (Ligand 03)

Summary for 5M0B
Entry DOI10.2210/pdb5m0b/pdb
Related5LCP 5LCQ 5LCR 5LCT 5LCU
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE, ... (6 entities in total)
Functional Keywordspka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase, ligand 03
Biological sourceCricetulus griseus (Chinese hamster)
More
Total number of polymer chains2
Total formula weight43773.74
Authors
Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-04, release date: 2018-06-06, Last modification date: 2024-01-17)
Primary citationWienen-Schmidt, B.,Jonker, H.R.A.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.506 Å)
Structure validation

217705

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