5LCT
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a R-methyl-piperazine substituted Fasudil-derivative (Ligand 02)
Summary for 5LCT
Entry DOI | 10.2210/pdb5lct/pdb |
Related | 5LCP 5LCQ 5LCR |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[(2~{R})-2-methylpiperazin-1-yl]sulfonylisoquinoline, ... (6 entities in total) |
Functional Keywords | pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, ligand 21, transferase |
Biological source | Cricetulus griseus (Chinese hamster) More |
Cellular location | Cytoplasm : P25321 |
Total number of polymer chains | 2 |
Total formula weight | 43813.80 |
Authors | Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-06-22, release date: 2018-01-17, Last modification date: 2024-01-10) |
Primary citation | Wienen-Schmidt, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G. Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.615 Å) |
Structure validation
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