5LCU

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a S-methyl-piperazine substituted Fasudil-derivative (Ligand 01)

Summary for 5LCU

• Entry DOI: 10.2210/pdb5lcu/pdb
• Related: 5LCP 5LCQ 5LCR 5LCT
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, ... (6 entities in total)
• Functional Keywords: pka, kinase, fasudil, inhibition, cocrystal, 3x-phosphorylated, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Cellular location: Cytoplasm : P25321
• Total number of polymer chains: 2
• Total formula weight: 43845.85

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-06-22, release date: 2018-01-17, Last modification date: 2024-10-09)

• Primary citation: Wienen, B.,Jonker, H.R.A.,Wulsdorf, T.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Parigi, G.,Luchinat, C.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.579 Å)