5M71

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with an (R)-methyl substitued Fasudil-derivative.

Summary for 5M71

• Entry DOI: 10.2210/pdb5m71/pdb
• Related: 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V 5M6Y
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[[(2~{R})-2-methyl-1,4-diazepan-4-ium-1-yl]sulfonyl]isoquinoline, ... (5 entities in total)
• Functional Keywords: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43678.62

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-26, release date: 2018-06-06, Last modification date: 2024-01-17)

• Primary citation: Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with differently methylated Fasudil-derived ligands; To be Published,

Experimental method

X-RAY DIFFRACTION (1.488 Å)