5M6Y

Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a methylisoquinoline Fasudil-derivative

Summary for 5M6Y

• Entry DOI: 10.2210/pdb5m6y/pdb
• Related: 5LCP 5LCQ 5LCR 5LCT 5LCU 5M0B 5M0C 5M0L 5M0U 5M6V
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline, ... (5 entities in total)
• Functional Keywords: pka, kinase, fasudil-derivative, inhibition, cocrystal, 3x-phosphorylated, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43763.75

Authors

Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2016-10-26, release date: 2018-06-06, Last modification date: 2024-11-06)

• Primary citation: Wienen-Schmidt, B.,Jonker, H.,Gerber, H.-D.,Saxena, K.,Kudlinzki, D.,Sreeramulu, S.,Heine, A.,Schwalbe, H.,Klebe, G.; Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with differently methylated Fasudil-derived ligands; To be Published,

Experimental method

X-RAY DIFFRACTION (1.367 Å)