5I0Q
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein
Summary for 5I0Q
| Entry DOI | 10.2210/pdb5i0q/pdb |
| Related | 5HYP 5HYT 5HYU 5HZP |
| Descriptor | M protein, serotype 2.1, C4b-binding protein alpha chain (3 entities in total) |
| Functional Keywords | m protein, complement, streptococcus pyogenes, hypervariable antigen, immune system |
| Biological source | Streptococcus pyogenes More |
| Cellular location | Secreted, cell wall ; Peptidoglycan-anchor : P50468 Secreted: P04003 |
| Total number of polymer chains | 2 |
| Total formula weight | 26664.72 |
| Authors | Buffalo, C.Z.,Bahn-Suh, A.J.,Ghosh, P. (deposition date: 2016-02-04, release date: 2016-07-20, Last modification date: 2016-10-26) |
| Primary citation | Buffalo, C.Z.,Bahn-Suh, A.J.,Hirakis, S.P.,Biswas, T.,Amaro, R.E.,Nizet, V.,Ghosh, P. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol, 1:16155-16155, 2016 Cited by PubMed: 27595425DOI: 10.1038/nmicrobiol.2016.155 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.293 Å) |
Structure validation
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