5HZP

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.

Summary for 5HZP

Entry DOI	10.2210/pdb5hzp/pdb
Related	5HYP 5HYT 5HYU 5I0Q
Descriptor	M protein, serotype 49, C4b-binding protein alpha chain, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	m protein, compliment, streptococcus pyogenes, hypervariable antigen, immune system
Biological source	Streptococcus pyogenes serotype M49 More
Total number of polymer chains	4
Total formula weight	50215.11
Authors	Buffalo, C.Z.,Bahn-Suh, A.J.,Ghosh, P. (deposition date: 2016-02-02, release date: 2016-07-20, Last modification date: 2019-12-11)
Primary citation	Buffalo, C.Z.,Bahn-Suh, A.J.,Hirakis, S.P.,Biswas, T.,Amaro, R.E.,Nizet, V.,Ghosh, P. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol, 1:16155-16155, 2016 Cited by PubMed: 27595425 DOI: 10.1038/nmicrobiol.2016.155 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74 Å)

Structure validation