5HZP

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, A)	M protein, serotype 49	polymer	90	10529.5	2	UniProt (P16947)	Streptococcus pyogenes serotype M49
2	C, D (B, D)	C4b-binding protein alpha chain	polymer	128	14340.7	2	UniProt (P04003) Pfam (PF00084)	Homo sapiens (Human)	C4bp,Proline-rich protein,PRP
3	E, F, G, H, I (C, B, D)	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
4	J, K, L, M (C, A, B, D)	water	water		18.0	20	Chemie (HOH)

Sequence modifications

C, A: 42 - 127 (UniProt: P16947)

PDB	External Database	Details
Gly 38	-	expression tag
Pro 39	-	expression tag
Gly 40	-	expression tag
Ser 41	-	expression tag

B, D: 1 - 124 (UniProt: P04003)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Mse 29	Leu 77	engineered mutation
Mse 46	Leu 94	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	49740.3
Non-Polymers*	Number of molecules	5
	Total formula weight	474.9
All*	Total formula weight	50215.1

*Water molecules are not included.