5I0Q

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	M protein, serotype 2.1	polymer	104	12500.8	1	UniProt (P50468) In PDB	Streptococcus pyogenes
2	B	C4b-binding protein alpha chain	polymer	128	14163.9	1	UniProt (P04003) Pfam (PF00084) In PDB	Homo sapiens (Human)	C4bp,Proline-rich protein,PRP
3		water	water		18.0	132	Chemie (HOH)

Sequence modifications

A: 42 - 141 (UniProt: P50468)

PDB	External Database	Details
Gly 38	-	expression tag
Pro 39	-	expression tag
Gly 40	-	expression tag
Ser 41	-	expression tag
Ala 65	Lys 65	engineered mutation
Ala 66	Asn 66	engineered mutation

B: 1 - 124 (UniProt: P04003)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	26664.7
All*	Total formula weight	26664.7

*Water molecules are not included.