5E4O

Human transthyretin (TTR) complexed with (Z)-((3,4-Dichloro-phenyl)-methyleneaminooxy)-acetic acid

Summary for 5E4O

Entry DOI	10.2210/pdb5e4o/pdb
Related	4TQ8 4TQH 4TQI 4TQP 5E23 5E4A
Descriptor	Transthyretin, ({(Z)-[(3,4-dichlorophenyl)(phenyl)methylidene]amino}oxy)acetic acid (3 entities in total)
Functional Keywords	fluorenone based fibrillogenesis inhibitor, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	26313.11
Authors	Ciccone, L.,Savko, M.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2015-10-06, release date: 2016-03-23, Last modification date: 2016-12-07)
Primary citation	Ciccone, L.,Nencetti, S.,Rossello, A.,Stura, E.A.,Orlandini, E. Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). J Enzyme Inhib Med Chem, 31:40-51, 2016 Cited by PubMed: 27067161 DOI: 10.3109/14756366.2016.1167048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation