4TQ8

Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR)

Summary for 4TQ8

Entry DOI	10.2210/pdb4tq8/pdb
Related	3GS0 3GS4 4TQH 4TQI
Descriptor	Transthyretin, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	ttr, inhibitor 15, forward and reverse binding modes, amyloid inhibitor, polyethylene glycol crystallization, hormone
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28213.41
Authors	Ciccone, L.,Orlandini, E.,Nencetti, S.,Rossello, A.,Stura, E.A. (deposition date: 2014-06-10, release date: 2015-06-24, Last modification date: 2023-12-27)
Primary citation	Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation