4TQH

Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)ethanoic acid

Summary for 4TQH

Entry DOI	10.2210/pdb4tqh/pdb
Related	3GS0 3GS4 4TQ8 4TQI 4TQP
Descriptor	Transthyretin, [(9H-fluoren-9-ylideneamino)oxy]acetic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transthyretin (ttr) complex, amyloid antagonist and inhibitor, fluorenone based inhibitor, dual binding mode, hormone
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28123.29
Authors	Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2014-06-11, release date: 2015-06-24, Last modification date: 2023-09-27)
Primary citation	Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.511 Å)

Structure validation