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3GS4

Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid (inhibitor 15)

Summary for 3GS4
Entry DOI10.2210/pdb3gs4/pdb
Related3GLZ 3GS0
DescriptorTransthyretin, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid (3 entities in total)
Functional Keywordstransthyretin, inhibitor, amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, polymorphism, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological sourceHomo sapiens (Human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28089.28
Authors
Mohamedmohaideen, N.N.,Palaninathan, S.K.,Orlandini, E.,Sacchettini, J.C. (deposition date: 2009-03-26, release date: 2009-07-28, Last modification date: 2023-09-06)
Primary citationPalaninathan, S.K.,Mohamedmohaideen, N.N.,Orlandini, E.,Ortore, G.,Nencetti, S.,Lapucci, A.,Rossello, A.,Freundlich, J.S.,Sacchettini, J.C.
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.
Plos One, 4:e6290-e6290, 2009
Cited by
PubMed: 19621084
DOI: 10.1371/journal.pone.0006290
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.78 Å)
Structure validation

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