4TQ8
Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR)
Summary for 4TQ8
Entry DOI | 10.2210/pdb4tq8/pdb |
Related | 3GS0 3GS4 4TQH 4TQI |
Descriptor | Transthyretin, 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | ttr, inhibitor 15, forward and reverse binding modes, amyloid inhibitor, polyethylene glycol crystallization, hormone |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28213.41 |
Authors | Ciccone, L.,Orlandini, E.,Nencetti, S.,Rossello, A.,Stura, E.A. (deposition date: 2014-06-10, release date: 2015-06-24, Last modification date: 2023-12-27) |
Primary citation | Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.52 Å) |
Structure validation
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