4TQI

Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode

Summary for 4TQI

Entry DOI	10.2210/pdb4tqi/pdb
Related	3GS0 4TQ8 4TQH 4TQP
Descriptor	Transthyretin, (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	peg ttr crystallization, flourenone based amyloid antagonist and inhibitor, prealbumin, dual binding mode, hormone transporter, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28301.52
Authors	Stura, E.A.,Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E. (deposition date: 2014-06-11, release date: 2015-06-24, Last modification date: 2023-09-27)
Primary citation	Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation