4TQP
Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode
Summary for 4TQP
Entry DOI | 10.2210/pdb4tqp/pdb |
Related | 4TQ8 4TQH 4TQI |
Descriptor | Transthyretin, (2R)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methyl-N-(methylsulfonyl)propanamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | polyethylene glycol ttr crystallization, forward and reverse binding modes, amyloid antagonist inhibitor, transthyretin, fluorenone based inhibitors, hormone |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28455.73 |
Authors | Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2014-06-11, release date: 2015-06-24, Last modification date: 2023-09-27) |
Primary citation | Ciccone, L.,Nencetti, S.,Rossello, A.,Tepshi, L.,Stura, E.A.,Orlandini, E. X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, :1-10, 2015 Cited by PubMed: 26235916PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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