4TQP
Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0003105 | biological_process | negative regulation of glomerular filtration |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0007603 | biological_process | phototransduction, visible light |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042562 | molecular_function | hormone binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140313 | molecular_function | molecular sequestering activity |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0003105 | biological_process | negative regulation of glomerular filtration |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0007603 | biological_process | phototransduction, visible light |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042562 | molecular_function | hormone binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140313 | molecular_function | molecular sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue 48R A 201 |
| Chain | Residue |
| A | LYS15 |
| A | LEU110 |
| A | LEU110 |
| A | SER117 |
| A | SER117 |
| A | THR118 |
| A | THR119 |
| A | THR119 |
| A | HOH305 |
| A | HOH305 |
| A | HOH356 |
| A | LEU17 |
| A | HOH425 |
| A | HOH425 |
| A | HOH429 |
| B | SER115 |
| A | LEU17 |
| A | PRO24 |
| A | SER52 |
| A | THR106 |
| A | ALA108 |
| A | ALA108 |
| A | ALA109 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue GOL A 202 |
| Chain | Residue |
| A | LEU110 |
| A | LEU111 |
| A | SER112 |
| A | SER115 |
| A | TYR116 |
| A | SER117 |
| A | HOH305 |
| A | HOH305 |
| A | HOH309 |
| A | HOH309 |
| A | HOH340 |
| B | LEU110 |
| B | SER112 |
| B | SER117 |
| B | HOH334 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | binding site for residue 48R B 201 |
| Chain | Residue |
| A | HOH309 |
| A | HOH309 |
| B | LYS15 |
| B | LYS15 |
| B | LEU17 |
| B | LEU17 |
| B | SER52 |
| B | THR106 |
| B | ALA108 |
| B | ALA108 |
| B | ALA109 |
| B | LEU110 |
| B | LEU110 |
| B | SER117 |
| B | SER117 |
| B | THR118 |
| B | THR119 |
| B | THR119 |
| B | VAL121 |
| B | HOH306 |
| B | HOH352 |
| B | HOH352 |
| B | HOH353 |
| B | HOH354 |
| B | HOH422 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| A | SER85 |
| A | PRO86 |
| A | PHE87 |
| A | TYR114 |
| A | HOH394 |
| B | THR96 |
| B | ASN98 |
| B | TYR105 |
| B | HOH395 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
