5E4A

Human transthyretin (TTR) complexed with (2,7-Dichloro-fluoren-9-ylideneaminooxy)-acetic acid.

Summary for 5E4A

Entry DOI	10.2210/pdb5e4a/pdb
Related	4TQ8 4TQH 4TQI 4TQP 5E23
Descriptor	Transthyretin, {[(2,7-dichloro-9H-fluoren-9-ylidene)amino]oxy}acetic acid (3 entities in total)
Functional Keywords	fluorenone based fibrillogenesis inhibitor, transthyretin, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	29799.23
Authors	Ciccone, L.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2015-10-05, release date: 2016-03-23, Last modification date: 2024-01-10)
Primary citation	Ciccone, L.,Nencetti, S.,Rossello, A.,Stura, E.A.,Orlandini, E. Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). J Enzyme Inhib Med Chem, 31:40-51, 2016 Cited by PubMed: 27067161 DOI: 10.3109/14756366.2016.1167048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation