5FPB
Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one
Summary for 5FPB
Entry DOI | 10.2210/pdb5fpb/pdb |
Related | 5FP3 5FP4 5FP7 5FP8 5FP9 5FPA |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ... (6 entities in total) |
Functional Keywords | oxidoreductase, inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q6B0I6 |
Total number of polymer chains | 1 |
Total formula weight | 39560.61 |
Authors | Chung, C. (deposition date: 2015-11-27, release date: 2016-01-27, Last modification date: 2024-05-08) |
Primary citation | Westaway, S.M.,Preston, A.G.S.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.,Diallo, H.,Douault, C.,Drewes, G.,Eagle, R.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Liddle, J.,Mosley, J.,Muelbaier, M.,Randle, R.,Rioja, I.,Rueger, A.,Seal, G.A.,Sheppard, R.J.,Singh, O.,Taylor, J.,Thomas, P.,Thomson, D.,Wilson, D.M.,Lee, K.,Prinjha, R.K. Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. J.Med.Chem., 59:1357-, 2016 Cited by PubMed: 26771107DOI: 10.1021/ACS.JMEDCHEM.5B01537 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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